| Primary Identifier | MGI:1351345 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 14823 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables group III metabotropic glutamate receptor activity. Predicted to be involved in several processes, including adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Predicted to be located in neuronal cell body and presynaptic membrane. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone membrane. Is expressed in several structures, including eye; gonad; ileum; liver and biliary system; and nervous system. Human ortholog(s) of this gene implicated in alcohol dependence; attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8). PHENOTYPE: Mice homozygous for a knock-out allele are overweight and mildly insulin resistant, and display increased anxiety-related responses and reduced exploration in a new environment. Mice homozygous for a different knock-out allele exhibit altered excitatory responses in the dentate gyrus. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
