Primary Identifier | MGI:2182081 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 192198 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in modulation of chemical synaptic transmission. Acts upstream of or within excitatory synapse assembly and postsynaptic density protein 95 clustering. Located in dendritic spine; excitatory synapse; and postsynaptic membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including branchial arch; central nervous system; metanephros; sensory organ; and vibrissa. Orthologous to human LRRC4 (leucine rich repeat containing 4). PHENOTYPE: Mice homozygous for a null allele exhibit hyperactivity, an absence of startle reflex, and abnormal ABR amplitude. [provided by MGI curators] |