Primary Identifier | MGI:2179061 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 243743 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables semaphorin receptor activity. Involved in several processes, including maintenance of synapse structure; nervous system development; and semaphorin-plexin signaling pathway. Acts upstream of or within nervous system development; regulation of axon extension involved in axon guidance; and regulation of negative chemotaxis. Is active in cerebellar climbing fiber to Purkinje cell synapse. Is expressed in several structures, including alimentary system; nervous system; and sensory organ. Orthologous to human PLXNA4 (plexin A4). PHENOTYPE: Homozygous null mice exhibit defective trajecotory and projection of peripheral sensory axons and sympathetic ganglion axons and the formation of the anterior commissure and the barrels. [provided by MGI curators] |