| Primary Identifier | MGI:107673 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 14187 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including NADP binding activity; geranylgeranyl reductase activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be located in extracellular region; lysosome; and mitochondrion. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and respiratory system. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10). PHENOTYPE: Mice with a knock-out allele exhibit shorter colon crypts, reduced proliferation and maturation of crypt cells, elevated levels of cytokines in the colon mucosa and increased susceptibility to induced colitis and colitis-associated tumorigenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
