| Primary Identifier | MGI:1925662 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 78412 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables damaged DNA binding activity and molecular adaptor activity. Involved in several processes, including DNA metabolic process; positive regulation of double-strand break repair via nonhomologous end joining; and protein localization to site of double-strand break. Part of DNA repair complex. Is active in site of double-strand break. Is expressed in several structures, including adipose tissue; alimentary system; eye; male reproductive gland or organ; and nervous system. Orthologous to human CYREN (cell cycle regulator of NHEJ). PHENOTYPE: Homozygous knockout increases sensitivity to ionizing radiation and affects B cell class switching recombination. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
