Primary Identifier | MGI:98586 | Organism | mouse, laboratory |
Chromosome | 6 | Mgi Type | gene segment |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in cell surface receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human TRBV12-3 (T cell receptor beta variable 12-3) and TRBV12-4 (T cell receptor beta variable 12-4). PHENOTYPE: Mice homozygous for a knock-in allele exhibit altered rearrangement and allelic exclusion of the nearest Vbeta segment in the double-negative compartment; however, feedback inhibition of Vbeta-to-DJbeta recombination remains intact in the double-positivecompartment. [provided by MGI curators] |