Primary Identifier | MGI:1349656 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 107526 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GTP binding activity. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol. Is expressed in male associated reproductive structure and renal vasculature. Orthologous to human GIMAP4 (GTPase, IMAP family member 4). PHENOTYPE: Mice homozygous for a knock-out allele show no detectable alterations in T-cell development, selection and activation; however, mutant T cells exhibit a delay in the execution of programmed cell death induced by intrinsic stimuli downstream of caspase-3 activation and phosphatidylserine exposure. [provided by MGI curators] |