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Protein Coding Gene : Tmem176b transmembrane protein 176B

Primary Identifier  MGI:1916348 Organism  mouse, laboratory
Chromosome  6 NCBI Gene Number  65963
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Acts upstream of or within negative regulation of dendritic cell differentiation. Predicted to be located in membrane and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TMEM176B (transmembrane protein 176B).
PHENOTYPE: Most mice homozygous for a knock-out allele exhibit severe sporadic ataxia and a small cerebellum associated with abnormal cerebellar lobulation, loss of the internal granule cell layer, poor formation of the external germinal layer, and disorganized Purkinje cells. [provided by MGI curators]
  • synonyms:
  • transmembrane protein 176B,
  • Clast1,
  • RIKEN cDNA 1810009M01 gene,
  • Tmem176b,
  • Lr8,
  • 1810009M01Rik

Features --> Cross References

Genome

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0 Exons

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0 Involved In Mutations

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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0 Driver For