| Primary Identifier | MGI:97374 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 109648 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables G protein-coupled receptor binding activity. Involved in synaptic signaling via neuropeptide. Acts upstream of or within regulation of blood pressure. Located in cytoplasm. Is active in GABA-ergic synapse. Is expressed in several structures, including adrenal gland; carotid body; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol dependence; alcohol use disorder; artery disease (multiple); and epilepsy (multiple). Orthologous to human NPY (neuropeptide Y). PHENOTYPE: Mice homozygous for a null allele exhibit sporadic mild seizures and increased susceptibility to PTZ-induced seizures. Mice homozygous for a different null allele show hypoactivity and reduced exploratory behavior, an increased anxiety-related response in males, and increased defecation in females. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
