Primary Identifier | MGI:96177 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 15402 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity. Acts upstream of or within several processes, including intestinal epithelial cell maturation; mammary gland development; and respiratory system development. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; gut; and skeleton. Orthologous to human HOXA5 (homeobox A5). PHENOTYPE: Nullizygous mice show skeletal defects, tracheal dysmorphology, reduced surfactant production, emphysema, and partial neonatal lethality. Survivors show stunted growth, delayed ear elevation and eyelid opening, and altered thyroid development, digestive secretion, and ovarian biology. [provided by MGI curators] |