| Primary Identifier | MGI:96171 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 15395 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Acts upstream of or within several processes, including embryonic limb morphogenesis; regionalization; and reproductive structure development. Part of transcription regulator complex. Is expressed in several structures, including embryo mesenchyme; genitourinary system; large intestine; limb; and nervous system. Orthologous to human HOXA10 (homeobox A10). PHENOTYPE: Homozygotes are viable with homeotic transformation of vertebrae and lumbar spinal nerves, misshapen femurs and degeneration of knee articulation. Males show cryptorchidism and testes dysmorphology. Females have uterine defects affecting embryo viability. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
