| Primary Identifier | MGI:96172 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 15396 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in mesodermal cell fate specification and positive regulation of DNA-templated transcription. Acts upstream of or within several processes, including embryonic morphogenesis; regionalization; and reproductive structure development. Part of protein-DNA complex and transcription regulator complex. Is expressed in several structures, including central nervous system; genitourinary system; limb; limb bud; and skeletal system. Human ortholog(s) of this gene implicated in radioulnar synostosis. Orthologous to human HOXA11 (homeobox A11). PHENOTYPE: Homozygotes for targeted null mutations exhibit homeotic transformations affecting thoracic and sacral vertebrae, and forelimb defects. Mutants are sterile due to malformed vas deferens and cryptorchism in males, and defective uteri in females. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
