Primary Identifier | MGI:3642509 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 791364 |
Mgi Type | lncRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in several processes, including hindlimb morphogenesis; neuromuscular process controlling posture; and post-anal tail morphogenesis. Acts upstream of or within neuromuscular process and skeletal muscle fiber development. Is expressed in several structures, including cartilage; limb; and limb bud. Orthologous to human HOTTIP (HOXA distal transcript antisense RNA). PHENOTYPE: Mice homozygous for a null allele exhibit limb grasping, decreased grip strength, muscle weakness, decreased gastrocnemius weight with a significant reduction in the number of muscle fibers, and shortened calcanea. [provided by MGI curators] |