| Primary Identifier | MGI:1289308 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 52440 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables kinase binding activity. Involved in negative regulation of NF-kappaB transcription factor activity. Predicted to be located in autophagosome; cytoplasmic vesicle; and phagophore assembly site. Predicted to be active in mitochondrion. Is expressed in central nervous system; genital tubercle; limb mesenchyme; and retina nuclear layer. Orthologous to human TAX1BP1 (Tax1 binding protein 1). PHENOTYPE: Knockout mice are born alive but fail to thrive and develop inflammatory cardiac valvulitis and dermatitis, die prematurely, and are hypersensitive to low doses of TNF and IL-1beta. In contrast, embryos homozygous for a gene trap mutation die at E13.5 from hemorrhaging and/or cardiac defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
