| Primary Identifier | MGI:1341839 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 107607 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables pattern recognition receptor activity and peptidoglycan binding activity. Involved in several processes, including nucleotide-binding activity oligomerization domain containing 1 signaling pathway; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of dendritic cell antigen processing and presentation. Acts upstream of or within several processes, including positive regulation of MAPK cascade; positive regulation of cytokine production; and positive regulation of xenophagy. Located in phagocytic vesicle. Is expressed in several structures, including alimentary system; autopod; brain; olfactory epithelium; and urinary system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human NOD1 (nucleotide binding oligomerization domain containing 1). PHENOTYPE: Homozygous mutant mice were viable, fertile, and appeared normal in a specific-pathogen free environment. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
