| Primary Identifier | MGI:2181693 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 209590 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cytokine binding activity; peptide hormone binding activity; and prolactin receptor activity. Predicted to contribute to interleukin-12 receptor binding activity; interleukin-23 binding activity; and interleukin-23 receptor activity. Predicted to be involved in several processes, including positive regulation of defense response to virus by host; regulation of cytokine production; and response to type II interferon. Predicted to act upstream of or within cell surface receptor signaling pathway via JAK-STAT and leukocyte mediated immunity. Predicted to be located in plasma membrane. Predicted to be part of interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); inflammatory bowel disease (multiple); pulmonary hypertension; and systemic scleroderma. Orthologous to human IL23R (interleukin 23 receptor). PHENOTYPE: Th17 T cells from homozygous null mice have less secretion of IL-9 upon secondary stimulation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
