| Primary Identifier | MGI:88347 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 12526 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable MHC class I protein binding activity and coreceptor activity. Predicted to be involved in T cell activation and T cell receptor signaling pathway. Located in external side of plasma membrane. Part of receptor complex. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to several human genes including CD8B (CD8 subunit beta). PHENOTYPE: Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
