| Primary Identifier | MGI:1336882 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 22320 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable SNAP receptor activity; chloride channel inhibitor activity; and syntaxin binding activity. Involved in SNARE complex assembly and mucus secretion. Acts upstream of or within several processes, including cellular response to type II interferon; positive regulation of pancreatic amylase secretion; and zymogen granule exocytosis. Located in several cellular components, including basolateral part of cell; basolateral plasma membrane; and cytoplasmic vesicle. Part of SNARE complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Orthologous to human VAMP8 (vesicle associated membrane protein 8). PHENOTYPE: Nullizygous mutations of this gene can lead to altered mast cell degranulation, abnormal zymogen granule release from pancreatic acinar cells and dense core granule release from platelets, increased resistance to induced pancreatitis, hydronephrosis, and partial postnatal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
