| Primary Identifier | MGI:2389173 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 74342 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Predicted to be located in several cellular components, including endoplasmic reticulum; excitatory synapse; and growth cone. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization membrane. Is expressed in several structures, including central nervous system; future brain; limb; peripheral nervous system; and sensory organ. Used to study schizophrenia. Orthologous to human LRRTM1 (leucine rich repeat transmembrane neuronal 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired cognitive function and altered hippocampal synapse morphology. When conditionally deleted in addition to Lrrtm2, mice homozygous for a conditional allele exhibit impaired basal AMPA receptor transmission and LTP. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
