| Primary Identifier | MGI:2389180 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 243499 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables heparan sulfate proteoglycan binding activity. Involved in regulation of synapse assembly. Acts upstream of or within AMPA glutamate receptor clustering; positive regulation of synapse assembly; and regulation of presynaptic membrane organization. Located in postsynaptic membrane. Part of AMPA glutamate receptor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and photoreceptor ribbon synapse. Is expressed in several structures, including central nervous system; embryo mesenchyme; and future midbrain. Orthologous to human LRRTM4 (leucine rich repeat transmembrane neuronal 4). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired excitatory synapse development and excitatory transmission in dentate gyrus granule cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
