| Primary Identifier | MGI:1914229 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 66979 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be involved in DNA-templated DNA replication. Predicted to be part of ATAC complex and epsilon DNA polymerase complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit). PHENOTYPE: Homozygous inactivation of this gene causes embryonic lethality and extensive developmental defects in inbred strains. In an outbred background, viable homozygotes show growth, craniofacial and skeletal anomalies, subfertility, defective B and T cell maturation, leukopenia, and tumor predisposition. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
