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Protein Coding Gene : Spin1 spindlin 1
Primary Identifier  MGI:109242 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  20729
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0)

Enables histone reader activity. Involved in protein localization to chromatin and transposable element silencing by piRNA-mediated DNA methylation. Located in spindle. Is active in chromatin. Is expressed in several structures, including 2-cell stage conceptus; alimentary system; brain; genitourinary system; and immune system. Orthologous to human SPIN1 (spindlin 1).
PHENOTYPE: Mice homozygous for a gene trapped allele display complete postnatal lethality. Although mutant female mice exhibit normal follicular development and oocyte growth, fully grown oocytes are defective in resuming meiosis. [provided by MGI curators]
  • synonyms:
  • expressed sequence AA553322,
  • MGD-MRK-38287,
  • MGI:2142957,
  • AA673430,
  • spindlin,
  • MGI:2145170,
  • Spin,
  • expressed sequence AA673430,
  • Spin1,
  • AA553322,
  • spindlin 1
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1 Involved In Mutations

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