Primary Identifier | MGI:107184 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 12468 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein folding chaperone and unfolded protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida. Located in cell body. Part of chaperonin-containing T-complex. Orthologous to human CCT7 (chaperonin containing TCP1 subunit 7). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture. [provided by MGI curators] |