| Primary Identifier | MGI:107914 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 21841 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mRNA 3'-UTR AU-rich region binding activity. Involved in negative regulation of translation and regulation of alternative mRNA splicing, via spliceosome. Acts upstream of or within negative regulation of cytokine production. Located in cytoplasmic stress granule and nuclear stress granule. Is expressed in several structures, including alimentary system; brain; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). PHENOTYPE: Homozygous null mice exhibit reduced postnatal survival and functional abnormalities in the immune system with no gross abnormalities in any of the major organs. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
