| Primary Identifier | MGI:1928760 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 56505 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ATPase binding activity; TFIID-class transcription factor complex binding activity; and adenyl ribonucleotide binding activity. Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Part of ribonucleoprotein complex. Is expressed in several structures, including branchial arch; cerebral cortex; embryo mesenchyme; genital swelling; and sensory organ. Orthologous to human RUVBL1 (RuvB like AAA ATPase 1). PHENOTYPE: Mice homozygous for a null allele show impaired proliferation of the pluripotent inner mass cells and embryonic lethality before implantation. Conditional ablation of this gene in hematopoietic tissues leads to bone marrow failure involving apoptotic loss of hematopoietic stem cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
