| Primary Identifier | MGI:1929988 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 66277 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in several processes, including cardiac muscle hypertrophy in response to stress; negative regulation of peptidyl-lysine acetylation; and podocyte differentiation. Acts upstream of or within several processes, including intracellular glucose homeostasis; positive regulation of D-glucose import; and response to insulin. Located in nucleus. Is expressed in several structures, including central nervous system; cranium; early conceptus; metanephros; and nose. Used to study aortic aneurysm. Orthologous to human KLF15 (KLF transcription factor 15). PHENOTYPE: Mice homozygous for a null allele display impaired gluconeogenesis with severe fasting induce hypoglycemia. Homozygotes are also more sensitive to induced cardiac stress and display mild cardiac and aortic abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
