| Primary Identifier | MGI:98961 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 22421 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables frizzled binding activity. Involved in several processes, including dendritic spine morphogenesis; modulation of chemical synaptic transmission; and reproductive structure development. Acts upstream of or within several processes, including blood vessel morphogenesis; central nervous system development; and embryonic limb morphogenesis. Located in cell surface and extracellular matrix. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; reproductive system; and sensory organ. Used to study Fuhrmann syndrome. Human ortholog(s) of this gene implicated in Fuhrmann syndrome and Schinzel type phocomelia. Orthologous to human WNT7A (Wnt family member 7A). PHENOTYPE: Homozygous mutants have skeletal abnormalities including absence of digits, especially of the forelimb, and sometimes absence of the ulna. Occasionally, there is an extra set of ribs. Both sexes are sterile due to abnormalities of the Mullerian duct. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
