| Primary Identifier | MGI:1352466 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 22026 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Involved in several processes, including p38MAPK cascade; positive regulation of embryonic development; and positive regulation of myoblast differentiation. Acts upstream of or within lipopolysaccharide-mediated signaling pathway; meiotic cell cycle; and spermatogenesis. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human NR2C2 (nuclear receptor subfamily 2 group C member 2). PHENOTYPE: Nullizygous mice show smaller body size, subfertility, defects in spermatogenesis and ovarian folliculogenesis, irregular estrous cycles, few/no preovulatory follicles and corpora lutea, increased granulosa cell apoptosis, and increased serum progesterone and estradiol levels after superovulation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
