| Primary Identifier | MGI:1925144 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 243548 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable zinc ion binding activity. Involved in several processes, including embryonic brain development; maintenance of postsynaptic density structure; and regulation of postsynaptic density assembly. Acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity. Located in apicolateral plasma membrane; cytoplasm; and lateral plasma membrane. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; primitive streak; and respiratory system. Orthologous to human PRICKLE2 (prickle planar cell polarity protein 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to electroconvulsive or PTZ-induced seizures. Mice heterozygous for a knock-out allele exhibit increased susceptibility to electroconvulsive seizures. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
