| Primary Identifier | MGI:1914004 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 108655 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and transcription coregulator binding activity. Involved in T follicular helper cell differentiation; nervous system development; and regulation of gene expression. Acts upstream of or within with a positive effect on regulation of androgen receptor signaling pathway. Acts upstream of or within several processes, including positive regulation of cell population proliferation; regulation of gene expression; and striated muscle tissue development. Located in nucleus. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and musculoskeletal system. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; congenital heart disease; esophagus adenocarcinoma; intellectual disability-severe speech delay-mild dysmorphism syndrome; and peritonitis. Orthologous to human FOXP1 (forkhead box P1). PHENOTYPE: Homozygous null mice display embryonic lethality with abnormal outflow tract septation, ventricular septal defects, abnormal cardiac valve morphology, decreased and irregular heart rate, thin ventricular compact zone, and edema. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
