| Primary Identifier | MGI:1920145 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 72895 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables histone H3K36 methyltransferase activity; histone H3K9 methyltransferase activity; and transcription corepressor activity. Involved in several processes, including regulation of DNA-templated transcription; regulation of chromatin organization; and regulation of synapse assembly. Located in euchromatin and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 23. Orthologous to human SETD5 (SET domain containing 5). PHENOTYPE: Homozygous inactivation of this gene causes embryonic or fetal lethality. Observed phenotypes include embryonic growth retardation, impaired neural tube formation, somitogenesis and cardiac development, abnormal vasculogenesis in embryos, yolk sacs and placentas, hemorrhage and increased apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
