| Primary Identifier | MGI:2429603 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 108960 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein dimerization activity; protein kinase activity; and signaling adaptor activity. Acts upstream of or within lipopolysaccharide-mediated signaling pathway; negative regulation of DNA-binding transcription factor activity; and positive regulation of NF-kappaB transcription factor activity. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human IRAK2 (interleukin 1 receptor associated kinase 2). PHENOTYPE: Mice homozygous for a null allele exhibit decreased susceptibility to endotoxin shock. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
