Primary Identifier | MGI:2652840 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 232334 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable transcription coactivator binding activity. Involved in negative regulation of cardiac muscle cell proliferation; negative regulation of hippo signaling; and regulation of primary metabolic process. Located in nucleus. Is expressed in lung; submandibular gland primordium; tooth; and vibrissa. Orthologous to human VGLL4 (vestigial like family member 4). PHENOTYPE: Mice homozygous for a null allele exhibit premature death associated with compensatory cardiac hypertrophy, increased cardiac contractility, and thickening of the aortic and pulmonary valves due to increased cellular proliferation. [provided by MGI curators] |