Primary Identifier | MGI:106463 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 28006 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and retromer complex binding activity. Predicted to be involved in protein localization to endosome and retrograde transport, endosome to Golgi. Part of WASH complex. Is expressed in several structures, including extraembryonic component; liver; and neural retina. Orthologous to several human genes including WASHC2A (WASH complex subunit 2A). PHENOTYPE: Mice homozygous for a knock-out allele exhibit placentation defects with abnormal trophoblast layer formation and complete lethality throughout fetal growth and development. [provided by MGI curators] |