| Primary Identifier | MGI:107399 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 16172 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables interleukin-17 receptor activity and signaling receptor binding activity. Involved in several processes, including T-helper 17 type immune response; interleukin-17-mediated signaling pathway; and positive regulation of cytokine production involved in inflammatory response. Acts upstream of or within positive regulation of interleukin-13 production and positive regulation of interleukin-5 production. Located in plasma membrane. Is expressed in heart and thymus primordium. Human ortholog(s) of this gene implicated in immunodeficiency 51. Orthologous to human IL17RA (interleukin 17 receptor A). PHENOTYPE: Homozygotes for a targeted null mutation exhibit delayed neutrophil recruitment and enhanced susceptibility to intranasal infection by Klibsiella pneumoniae. Mice homozygous for a different knock-out allele exhibit delayed and milder IMQ-induced psoriasis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
