Primary Identifier | MGI:1917060 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 69810 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable carbohydrate binding activity and pattern recognition receptor activity. Acts upstream of or within positive regulation of release of sequestered calcium ion into cytosol. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC4C (C-type lectin domain family 4 member C). PHENOTYPE: Mice homozygous for a null allele exhibit reduced numbers of monocyte-derived inflammatory cells at mycobacterial infection sites, impaired IFN-gamma production by T cells and increased bacterial load. [provided by MGI curators] |