| Primary Identifier | MGI:2178323 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 232370 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cell-cell adhesion mediator activity; enzyme inhibitor activity; and neurexin family protein binding activity. Involved in several processes, including cold-induced thermogenesis; regulation of synapse assembly; and synapse assembly. Acts upstream of or within several processes, including chemical synaptic transmission; positive regulation of protein localization to synapse; and positive regulation of synapse assembly. Located in cell surface; postsynaptic density; and postsynaptic membrane. Part of protein-containing complex. Is active in several cellular components, including GABA-ergic synapse; lipid droplet; and postsynaptic density membrane. Is expressed in brain; central nervous system; cerebellum; dentate gyrus subgranular zone; and testis. Orthologous to human CLSTN3 (calsyntenin 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reductions in excitatory and inhibitory synapse density and deficits in synaptic transmission. Whole-body KO results in reduced sensitivity to diet-induced obesity, reduced body weight and fat amount and increased energy expenditure. It, and neuron-specific homozygous KO, also causes reduction in bone marrow volume, bone mass and femur length. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
