| Primary Identifier | MGI:1315211 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 14792 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in several processes, including glycerophospholipid metabolic process; intestinal stem cell homeostasis; and plasma lipoprotein particle assembly. Acts upstream of or within regulation of plasma lipoprotein particle levels. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; hemolymphoid system; and liver. Orthologous to human LPCAT3 (lysophosphatidylcholine acyltransferase 3). PHENOTYPE: Nullizygous mice show low blood glucose levels and postnatal death. Intestine-specific knockouts fail to thrive and show enterocyte lipid accumulation and low plasma triglycerides (TGs). Liver-specific knockouts show low plasma TGs, fatty liver, and secrete VLDL lacking arachidonoyl phospholipids. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
