| Primary Identifier | MGI:102520 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 12034 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables sphingolipid binding activity. Involved in several processes, including positive regulation of non-canonical NF-kappaB signal transduction; regulation of cytochrome-c oxidase activity; and regulation of gene expression. Acts upstream of or within several processes, including mammary gland development; negative regulation of intracellular estrogen receptor signaling pathway; and negative regulation of mammary gland epithelial cell proliferation. Located in cell surface; mitochondrial inner membrane; and nucleus. Part of mitochondrial prohibitin complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human PHB2 (prohibitin 2). PHENOTYPE: Homozygous mutant embryos die before E9. Heterozygous females exhibit a greater gain in body weight from 9-26 weeks of age and reduced litter sizes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
