| Primary Identifier | MGI:106588 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 16768 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables MHC class II protein binding activity and transmembrane signaling receptor activity. Involved in several processes, including cell surface receptor signaling pathway; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Acts upstream of or within negative regulation of interleukin-2 production and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3). PHENOTYPE: Mice homozygous for disruptions in this gene have a generally normal phenotype but do display reduced natural killer cell activity and increased T cell response to infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
