| Primary Identifier | MGI:97380 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 18205 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable nerve growth factor binding activity; nerve growth factor receptor binding activity; and receptor ligand activity. Acts upstream of or within several processes, including nervous system development; neuromuscular synaptic transmission; and positive regulation of transcription by RNA polymerase II. Located in cytoplasmic vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study atrial heart septal defect 1 and tetralogy of Fallot. Human ortholog(s) of this gene implicated in Alzheimer's disease and asthma. Orthologous to human NTF3 (neurotrophin 3). PHENOTYPE: Homozygotes for targeted null mutations exhibit loss of peripheral sensory and sympathetic neurons, lack of spinal propioceptive afferents and their sense organs, impaired suckling and movement, and postnatal lethality. Heterozygotes show mild defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
