Primary Identifier | MGI:95520 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 14177 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within cartilage condensation and myoblast differentiation. Predicted to be located in sarcolemma. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; limb; and skeletal musculature. Orthologous to human FGF6 (fibroblast growth factor 6). PHENOTYPE: Homozygotes for targeted null mutations appear phenotypically normal, but exhibit a defect in skeletal muscle regeneration following injury. Mutant myoblasts show decreased migrational ability. [provided by MGI curators] |