| Primary Identifier | MGI:3043083 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 381813 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; protein homodimerization activity; and protein methyltransferase activity. Involved in regulation of modification of postsynaptic actin cytoskeleton. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; sensory organ; spinal cord; and trigeminal ganglion. Orthologous to human PRMT8 (protein arginine methyltransferase 8). PHENOTYPE: Mice homozygous for a knockout allele exhibit abnormal Purkinje cell dendrite morphology, hyperactivity, limb grasping and gait abnormalities, and show reduced levels of acetylcholine and choline along with increased phosphatidylcholine levels in the cerebellum. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
