| Primary Identifier | MGI:2137670 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 56449 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; mRNA 3'-UTR binding activity; and ribonucleoprotein complex binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including male gonad development; negative regulation of skeletal muscle tissue development; and positive regulation of organ growth. Located in cytoplasm and nucleus. Is active in synapse. Is expressed in several structures, including brain; branchial arch; jaw; limb bud; and sensory organ. Orthologous to human YBX3 (Y-box binding protein 3). PHENOTYPE: Half of mice homozygous for a knock-out allele exhibit male infertility associated with smaller testes and reduced sperm production, partly due to increased spermatocyte apoptosis during mid to late spermatogenesis and progressive seminiferous tubule degeneration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
