| Primary Identifier | MGI:1891250 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 232431 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein kinase activator activity. Involved in negative regulation of epidermal growth factor-activated receptor activity. Located in plasma membrane. Is expressed in several structures, including gut; nose; respiratory system; submandibular gland primordium; and urinary system. Orthologous to human GPRC5A (G protein-coupled receptor class C group 5 member A). PHENOTYPE: Mice homozygous for one knock-out allele are healthy and exhibit normal lung development and a normal life span. A different homozygous KO allele causes a significantly increased incidence of acidophilic macrophage pneumonia and spontaneous lung tumors at 1-2 years of age. Another different homozygous KO results in age-related and diabetes-related pathology in kidney glomeruli. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
