| Primary Identifier | MGI:95821 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 14812 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables NMDA glutamate receptor activity and calcium channel activity. Involved in negative regulation of dendritic spine maintenance and regulation of synaptic plasticity. Acts upstream of or within several processes, including behavioral fear response; detection of mechanical stimulus involved in sensory perception of pain; and learning or memory. Located in several cellular components, including cytoplasmic vesicle; lysosome; and synaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including adipose tissue; central nervous system; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy 27; neurodegenerative disease (multiple); and nicotine dependence. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B). PHENOTYPE: Homozygotes for targeted null mutations exhibit impairments in suckling, hippocampal long term depression, and pattern formation of trigeminal nucleus sensory afferent terminals. Mutants die shortly after birth. Kinase-dead mutants display ant-depressive behavior. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
