| Primary Identifier | MGI:1097152 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 19277 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables Wnt-protein binding activity; protein homodimerization activity; and protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; and plasma membrane bounded cell projection organization. Located in apical plasma membrane; dendritic spine; and lateral plasma membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O). PHENOTYPE: Mice homozygous for one allele display impaired glomerular filtration due to podocyte structural anomalies and a predisposition for hypertension. Mice homozygous for a second allele exhibit susceptibility to pharmacologically induced seizures. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
