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Protein Coding Gene : Plcz1 phospholipase C, zeta 1
Primary Identifier  MGI:2150308 Organism  mouse, laboratory
Chromosome  6 NCBI Gene Number  114875
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables phosphatidylinositol phospholipase C activity. Involved in positive regulation of cytosolic calcium ion concentration involved in egg activation. Acts upstream of or within calcium ion transport and egg activation. Located in nucleolus; nucleoplasm; and pronucleus. Is expressed in several structures, including alimentary system; heart; integumental system; limb; and nervous system. Human ortholog(s) of this gene implicated in spermatogenic failure 17. Orthologous to human PLCZ1 (phospholipase C zeta 1).
PHENOTYPE: Homozygous knockout mice display normal spermatogenesis and sperm motility but are sub-fertile because of a failure to induce Ca2+ oscillations in oocytes. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 1700041H07 gene,
  • phospholipase C, zeta 1,
  • 1700041H07Rik,
  • Plcz1
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