| Primary Identifier | MGI:96382 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 15874 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable hormone activity; identical protein binding activity; and lipid binding activity. Acts upstream of or within negative regulation of bone resorption; negative regulation of osteoclast differentiation; and sensory perception of pain. Located in extracellular space. Is expressed in embryo; pancreas; pancreas primordium; and pancreas trunk epithelium. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human IAPP (islet amyloid polypeptide). PHENOTYPE: Homozygous inactivation of this locus increases glucose tolerance in a gender-dependent manner and results in decreased bone density due to increased bone resorption. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
