| Primary Identifier | MGI:103021 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 19691 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable 3'-5' DNA helicase activity; double-stranded DNA helicase activity; and four-way junction helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication; double-strand break repair via homologous recombination; and replication fork processing. Predicted to be located in nucleoplasm. Predicted to be active in chromosome and cytoplasm. Is expressed in cerebral cortex subventricular zone. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and pancreatic cancer. Orthologous to human RECQL (RecQ like helicase). PHENOTYPE: Homozygous mutation of this gene results in chromosomal instability, with embryonic fibroblasts exhibiting aneuploidy, spontaneous chromosomal breakage, frequent translocation events, increased sensitivity to ionizing radiation, and increased frequency of sister chromatid exchange. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
